Postdoc Positions: Subsequent-generation Single-molecule Imaging

Memorial Sloan Kettering Cancer Center

Job title: “Postdoc Positions: Subsequent-generation Single-molecule Imaging”

Firm: “Memorial Sloan Kettering Most cancers Heart”

Anticipated wage: “$61150 – 80315 per 12 months”

Location: “New York Metropolis, NY”

Job description: Pay Vary: $61,150-$80,315 Firm Overview:

The folks of Memorial Sloan Kettering Most cancers Heart (MSK) are united by a singular mission: ending most cancers for all times. Our specialised care groups present customized, compassionate, skilled care to sufferers of all ages. Knowledgeable by primary analysis executed at our Sloan Kettering Institute, scientists throughout MSK collaborate to conduct revolutionary translational and medical analysis that’s driving a revolution in our understanding of most cancers as a illness and enhancing the power to forestall, diagnose, and deal with it. MSK is devoted to coaching the subsequent era of scientists and clinicians, who go on to pursue our mission at MSK and across the globe. One of many world’s most revered complete facilities devoted solely to most cancers, we have now been acknowledged as one of many prime two most cancers hospitals within the nation by U.S. Information & World Report for greater than 30 years.

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We’re looking for to recruit excellent Postdoctoral Fellows/Associates to hitch us within the Pertsinidis lab within the Structural Biology Program at Sloan Kettering Institute/MSKCC in New York Metropolis.

Our lab develops cutting-edge single-molecule detection and super-resolution optical imaging methods, and applies these instruments to visualise and perceive among the most basic organic processes that energy mobile life. Examples embody modulation interferometry, a single-molecule localization-based super-resolution method with 1-2 nm 3D precision and target-locking 3D nanoscopy, a method that achieved single-molecule detection in excessive background, crowded intracellular environments. These instruments have enabled among the highest decision single-molecule research up to now, offering new organic insights that might not be obtained earlier than (e.g. Wang et al., Cell 2016; Li et al., Cell 2019).

You’ll have the possibility to turn into an necessary member of our vibrant, interdisciplinary crew, comprising a number of bodily and organic scientists. You’ll have the chance to interrupt new grounds in optical imaging, in situ structural biology and organic discovery. Some present pursuits:

1) constructing the next-generation single-molecule methods – to visualise organic processes in reside cells with (sub)-millisecond temporal and (sub)-nanometer 3D spatial decision;

2) pushing the boundaries of extracting high-resolution info from weak alerts in optically inhomogeneous, multi-cellular environments – tissue explants, 3D organoids and creating embryos;

3) developing novel single-molecule imaging-based discovery platforms, for each primary biology in addition to necessary biomedical purposes (drug discovery, cell-based therapeutics);

4) creating new single-molecule imaging and machine studying applied sciences for in situ structural biology – to allow for the primary time high-resolution structural research inside cells.

Necessities:

  • Want to sort out excellent challenges in optics, microscopy and/or single-molecule biology
  • PhD diploma in Physics, Chemistry, Optics, Optical Engineering, Biophysics or a related scientific or engineering subject.
  • Means to work successfully in a collaborative, multidisciplinary surroundings.

Expertise with single-molecule detection instrumentation and excessive/super-resolution optical imaging (e.g. STED/RESOLFT, 4Pi, MINFLUX, SIM, LLS/SPIM approaches, Adaptive Optics, and many others.), in addition to cryogenics and UHV applied sciences is most popular however not required. Robust computational expertise (e.g. laptop imaginative and prescient, deep studying) is a plus. People with further working information in areas of biochemistry, molecular, cell and developmental biology and/or genetics are strongly inspired to use.

When you’ve got questions on this chance, please attain out to:

Dr. Alexandros Pertsinidis

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Please embody on this utility a CV, names and speak to info of three references, and a brief description of scientific pursuits

Wage Vary: $61,150-$80,315

#LI-Onsite Closing:

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